Influence of Alpha-ketoglutarate on Cortical Bone Atrophy after Denervation of the Humerus in Turkey
نویسندگان
چکیده
The purpose of this study was to determine the influence of alpha-ketoglutarate (AKG) daily administration via the digestive tract on cortical bone loss. Due to structural and physiological properties, the study was executed on humerus model in turkey. The neurectomy of the radial and mediano-ulnar nerves was applied to induce osteopenic effect in the right humerus. The experiment was conducted from the 22 d after hatching, when the turkeys were subjected to neurectomy and AKG administration was started (0.4 g/kg b.w./d). After 14 weeks of the experiment, the animals were sacrificed. Right and left humeri were X-rayed, isolated and frozen at –25C until further analyses. Using quantitative computed tomography (QCT) method, volumetric bone density of the cortical bone compartment was estimated. Moreover, geometrical and mechanical properties of the investigated bones were determined. The obtained results indicate that AKG daily administration inhibits cortical bone loss induced by denervation of the humerus in turkey.
منابع مشابه
Long-term denervation of the humerus in turkeys as an experimental model for osteopenia.
The aim of this study was to evaluate the influence of long-term denervation on volumetric bone mineral density, and geometrical and mechanical properties of the humerus in turkeys. The experiment was conducted from d 22 after hatching until wk 17 of life. All experimental birds (male turkeys) were randomly divided into 2 weight-matched groups. The first group of turkeys served as the control g...
متن کاملRevision Fixation of Distal Humerus Fracture Nonunions in Older Age Patients with Poor Bone Quality or Bone Loss – Is This Viable as a Long-term Treatment Option?
Background: The purpose of this retrospective study was to analyze the long-term results of revision ORIF, jointcontracture release, and autogenous bone-grafting in the treatment of distal humerus frac-ture nonunions in older agedpatients with poor bone quality or bone loss who would have been candidates for total elbow arthroplasty.Methods: Seven patients (average age at inde...
متن کاملAneurysmal Bone Cyst: An Analysis of 38 Cases and Report of Four Unusual Surface Ones
Aneurysmal bone cyst (ABC) is a benign expansile bone tumor, most commonly involving the medulla of long bones. ABC rarely arises within the cortex or in the subperiosteal region, radiographically mimicking other conditions, in particular surface osteosarcomathat is low-grade in nature and may go secondary ABC changes, and telangiectatic osteosarcoma. Both of these are sometimes mistaken mic...
متن کاملاثرات تجویز هورمون رشد بر دانسیته استخوانی در خرگوش بالغ سالم
Background: The effects of growth hormone (GH) on bone density in healthy adults is controversial. This study was performed to evaluate the effects of GH administration on bone density under controlled conditions in healthy adult rabbits. Methods: Twenty healthy adult New Zealand white rabbits of both sexes were included in the study. The rabbits were divided into two groups. The experiment gr...
متن کاملDevastation of bone tissue in the appendicular skeleton parallels the progression of neuromuscular disease.
A mouse model of spinal muscular atrophy with respiratory distress (SMARD1) was used to study the consequences of neuromuscular degenerative disease on bone quantity and morphology. Histomorphometry and micro-computed tomography were used to assess the cortical and cancellous bone in the tibia, femur and humerus of adult neuromuscular degeneration (nmd) mice (up to 21w) and age-matched wild-typ...
متن کامل